Early Detection of Transplant-Related Lung Injury with CT
Bronchiolitis obliterans syndrome (BOS) is a serious lung complication after hematopoietic cell transplantation that leads to progressive airway obstruction and reduced survival. Diagnosis is typically based on pulmonary function testing, which may only detect disease after significant and often irreversible lung damage has occurred.
In this work, quantitative CT (qCT) was used to extract voxel-level measures of lung function from inspiratory and expiratory scans. Metrics such as air trapping and regional lung strain were evaluated to identify early disease and distinguish between BOS subtypes. Compared to standard imaging and pulmonary function testing, qCT demonstrated the ability to detect early BOS and differentiate disease severity with strong diagnostic performance.
Publication Link: ASH Publications
Figure A: Visual abstract from the study illustrating the use of quantitative CT to identify early bronchiolitis obliterans syndrome and differentiate disease subtypes based on imaging-derived metrics.